The Connecticut Separation Science Council and the Connecticut Mass Spec Discussion Group invite you to attend a joint meeting on September 8th, 2015 at the Meriden Four Points Hotel
Time: 5:30 – 7:00, Dinner Served
Location: 275 Research Pkwy, Meriden, CT 06450
Dr. Jeffrey W. Hudgens,
Institute for Bioscience and Biotechnology Research, BioProcess Measurements Group, Biomolecular Measurement Division National Institute of Standards and Technology, Rockville, MD
Hydrogen-Deuterium Exchange Mass Spectrometry: A Valuable Tool for the Biopharmaceutical Industry
Many biopharmaceutical companies have established hydrogen-deuterium exchange mass spectrometry (HDX-MS) laboratories. These facilities contribute to the research of drug mechanisms, of protein-ligand interactions, and of determinations of protein functional changes induced by environmental and post-translational modifications. Evaluations of HDX-MS data can determine protein-ligand interactions in terms of three-dimensional protein structure, and it can establish similarity among different glycoproteins. To develop a HDX-MS program that is responsive to the needs of the biopharmaceutical industry, our NIST laboratory has conducted research 1) that is determining the interlaboratory reproducibility of HDX-MS; 2) that introduces electron transfer dissociation (ETD) into HDX-MS, resulting in the ability to distinguish the effects of the glycan structure upon ligand binding; and 3) that accelerates elucidation of regulating mechanisms in proteins.
September's meeting is sponsored by ThermoFIsher Scientific.