The Connecticut Separation Science Council and the Connecticut Mass Spec Discussion Group invite you to attend a joint meeting on September 8th, 2015 at the Meriden Four Points Hotel

Time: 5:30 – 7:00, Dinner Served

Location: 275 Research Pkwy, Meriden, CT 06450

Registration: www.ctmsdg.org

Featured Speaker:

Dr. Jeffrey W. Hudgens,

Institute for Bioscience and Biotechnology Research, BioProcess Measurements Group, Biomolecular Measurement Division National Institute of Standards and Technology, Rockville, MD

Presentation:

Hydrogen-Deuterium Exchange Mass Spectrometry: A Valuable Tool for the Biopharmaceutical Industry

Many biopharmaceutical companies have established hydrogen-deuterium exchange mass spectrometry (HDX-MS) laboratories. These facilities contribute to the research of drug mechanisms, of protein-ligand interactions, and of determinations of protein functional changes induced by environmental and post-translational modifications. Evaluations of HDX-MS data can determine protein-ligand interactions in terms of three-dimensional protein structure, and it can establish similarity among different glycoproteins. To develop a HDX-MS program that is responsive to the needs of the biopharmaceutical industry, our NIST laboratory has conducted research 1) that is determining the interlaboratory reproducibility of HDX-MS; 2) that introduces electron transfer dissociation (ETD) into HDX-MS, resulting in the ability to distinguish the effects of the glycan structure upon ligand binding; and 3) that accelerates elucidation of regulating mechanisms in proteins.

September's meeting is sponsored by ThermoFIsher Scientific.